High-risk basal cell carcinoma: an update
| Autor: | Claudia Krönert, Thomas Kittner, Friedemann Pabst, Johannes Schorcht, Eckart Klemm, Uwe Wollina, Gunter Haroske |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
medicine.medical_specialty Electrochemotherapy Frozen section procedure Chemotherapy integumentary system business.industry medicine.medical_treatment Dermatology medicine.disease Radiation therapy Clinical trial Lymphatic system Internal medicine medicine Mohs surgery Basal cell carcinoma skin and connective tissue diseases business |
| Zdroj: | Expert Review of Dermatology. 5:357-368 |
| ISSN: | 1746-9880 1746-9872 |
| DOI: | 10.1586/edm.10.27 |
| Popis: | High-risk basal cell carcinoma (BCC) is an aggressive malignant tumor of the skin, with a potential of perineural, lymphatic and vascular spreading. This review presents the most common types and anatomical sites of high-risk BCC, and evaluates the diagnosis, clinical presentation and treatment options available. Based on the current data, micrographically controlled (Mohs) surgery or frozen section controlled excision is the treatment of choice. In cases with impossible complete tumor resection, radiotherapy is an alternative. In patients with a high risk of recurrence, adjuvant radiotherapy is used. Medical treatment of high-risk BCC is rather limited. Metastatic BCC have been treated with cisplatin-based chemotherapy. Chemo-immunotherapy, monoclonal antibodies and electrochemotherapy have been used more recently, but only case reports have been published. There is a need for controlled clinical trials. Regular follow-up is necessary in patients with high-risk BCC, but as yet no international consensus ... |
| Databáze: | OpenAIRE |
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