Diagnostic and prognostic value of selenium and Selenoprotein P in patients with comorbid course of nonalcoholic fatty liver disease and arterial hypertension

Autor:	Natalia Zhelezniakova, Iryna Tverezovska
Rok vydání:	2022
Předmět:	General Medicine
Zdroj:	Medicinski casopis. 56:68-76
ISSN:	2406-0380 0350-1221
DOI:	10.5937/mckg56-36421
Popis:	Objective. To evaluate the diagnostic and prognostic value of Selenoprotein P and selenium in the progression of liver damage in patients with nonalcoholic fatty liver disease (NAFLD). Methods. The study involved 120 patients: 50 with isolated NAFLD, 50 with comorbid NAFLD and hypertension, established according to the global and local guidelines. The control group included 20 relatively healthy volunteers. Liver function parameters, selenium and Selenoprotein P levels were assessed, and predictors of steatohepatitis were identified. Pearson's ch2, Mann-Whitney test, logistic regression was used. Results. The study found significant predominance of levels of Selenoprotein P (Sel P) and selenium in controls (71.0 (54.3; 76.1) ng/ml and 108.0 (96.9; 118.8) ng/ml respectively) compared with the NAFLD + hypertension (19.7 (8.0; 26.7) ng/ml and 43.5 (39.9; 49.1) ng/ml, p
Databáze:	OpenAIRE
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