Angiotensin-Converting Enzyme Gene Polymorphism and N-Acetyl-β-D-Glucosaminidase Excretion in Endemic Nephropathy
| Autor: | Živka Dika, Ksenija Vitale, Marica Miletić-Medved, Ivan Pećin, Dinko Novaković, Ninoslav Leko, Ante Cvitković, Bojan Jelaković, Jelena Kos, Jadranka Sertić, Dubravka Čvorišćec |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Proteinuria biology urogenital system business.industry Angiotensin-converting enzyme General Medicine urologic and male genital diseases Excretion Endocrinology Tubular proteinuria Nephrology Internal medicine Renin–angiotensin system Genotype medicine biology.protein Gene polymorphism medicine.symptom business Allele frequency |
| Zdroj: | Nephron Clinical Practice. 119:c105-c112 |
| ISSN: | 1660-2110 |
| DOI: | 10.1159/000327528 |
| Popis: | Background: Tubular proteinuria and enzymuria are hallmarks of endemic nephropathy (EN). The role of I/D angiotensin convertase (ACE) gene polymorphism has not yet been elucidated in this peculiar chronic tubulointerstitial nephritis, and our aim was to investigate the role of this polymorphism in EN focusing on the urinary N-acetyl-β-D-glucosaminidase (NAG) excretion, a biomarker of proximal tubular damage. Methods:ACE genotype and allele frequencies were determined in 229 farmers (147 women and 82 men) from an endemic Croatian village. The farmers were stratified according to the WHO criteria into the following subgroups: those ‘at risk’ for EN (n = 37), ‘suspected of having EN’ (n = 57), and ‘others’ (n = 135). Results: There were 74 (32.3%) subjects homozygous for the D allele, 99 (43.2%) heterozygous (ID genotype) and 56 (24.4%) homozygous for the I allele. No differences in allele frequency were found between the established WHO subgroups (p > 0.05). In the whole group, DD subjects had significantly higher values of diastolic blood pressure (p = 0.003) and urinary NAG than subjects with ID and II genotype (5.5 ± 1.2 vs. 4.0 ± 3.0 vs. 3.8 ± 4.2, respectively; p = 0.023). The highest values of serum creatinine (p = 0.02), proteinuria (p = 0.03) and urinary NAG (6.0 ± 3.7 vs. 3.7 ± 2.1 vs. 3.0 ± 1.6, respectively; p = 0.008) were observed in those suspected of having EN group with the DD genotype. Conclusion:ACE gene polymorphism is not a risk factor for EN. However, it might influence the clinical course of EN, and increased excretion of NAG might be a prognostic marker of this chronic tubulointerstitial nephritis. |
| Databáze: | OpenAIRE |
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