Evaluation of cytokine responses to equine herpesvirus 1 infection in balb/c mice
| Autor: | Stephanie Pradhan, Nitin Virmani, Taruna Anand, Aashwina Madhwal, Rhushikesh S. Khetmalis, K. Supriya, Bidhan Chandra Bera, Venkataramireddy Balena, B.N. Tripathi |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases. 41:166-173 |
| ISSN: | 0974-0147 0970-9320 |
| DOI: | 10.5958/0974-0147.2020.00019.7 |
| Popis: | Equine herpesvirus 1, an OIE notifiable, highly contagious disease of equines, causes significant economic losses by inducing abortions in pregnant mares, respiratory disease, neurological disorders, and early neonatal death in foals. The present study was conducted for ascertaining the onset of cytokine response shown by the mice infected with wild EHV1 strain. Various cytokines viz. IL-1, IL-2, IL-10, IL-17, IFN, IFN, and TNF were estimated from the pooled serum samples collected from the infected mice at specified intervals. Type I IFN and type II IFN that mainly helps in developing immunity against viral infection were detected from 3 to 9 dpi followed by a gradual decline. Pro-inflammatory cytokines like IL1, IL-17, and TNF peaked at 3 dpi. However, IL-17 response was seen only on 3 dpi after which it went undetected. On the other hand, IL-1 could be detected till 9 dpi whereas TNF response was seen throughout the experiment. IL-10, the anti-inflammatory cytokine, peaked on 3 dpi. IL-2, a marker of activation and proliferation of T cells was detected only on 3 dpi. The results suggested that a high level of TNF may cause untoward effects, while IL-1, IL-2 and IFNs may be important for effective virus clearance. The present study throws some light on the onset of an innate immune response in mice infected with wild EHV1 strain that further helps to trigger the adaptive arm of the host immune response. This will help in the understanding of immune response against EHV1. |
| Databáze: | OpenAIRE |
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