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The etiology of chronic diarrhea that affects a majority of AIDS patients is often obscure (Kotler et al., 1995). Recent light and electron microscopic study of intestinal biopsies from symptomatic AIDS patients disclosed bacterial colitis with three patterns of bacterium-enterocyte interaction: attaching and effacing, typical of enteropathogenic Escherichia coli (EPEC); loose adherence, suggestive of enteroaggregative E. coli (EAggEC); and microvillous-intercalation, suggestive of diffusely adherent E. coli (DAEC) (Orenstein & Kotler, 1995). |
