Increased Myogenic Responses in Uterine but not Mesenteric Arteries from Pregnant Offspring of Diet-Restricted Rat Dams1
| Autor: | Sukrutha Veerareddy, Denise G. Hemmings, Sandra T. Davidge, Philip N. Baker |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Pregnancy Offspring Cell Biology General Medicine Biology medicine.disease Nitric oxide synthase Endocrinology medicine.anatomical_structure Reproductive Medicine In utero Internal medicine medicine Vascular resistance biology.protein Animal studies Maternal undernutrition Mesenteric arteries |
| Zdroj: | Biology of Reproduction. 72:997-1003 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod.104.035675 |
| Popis: | Results of epidemiological and animal studies suggest a link between poor in utero growth and cardiovascular disease in adult offspring. Few studies, however, have examined the effects of maternal undernutrition on the vasculature of pregnant female offspring, and to our knowledge, no studies have examined myogenic responses, which are essential to vascular tone development, in these animal models. Thus, myogenic responses were assessed in radial uterine arteries of pregnant female offspring to determine if diet restriction during pregnancy could contribute to transgenerational effects. These results were compared to those in mesenteric arteries, which greatly contribute to peripheral vascular resistance. Myogenic responses in the presence and absence of inhibitors for nitric oxide synthase (NOS) and prostaglandin H synthase (PGHS) were measured in arteries isolated from pregnant, 3-mo-old female offspring of control-fed (Coff) and globally diet-restricted (DRoff) rat dams. Although no difference... |
| Databáze: | OpenAIRE |
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