ChemInform Abstract: Enantioselective Desymmetrization of Prochiral Allenic Diols via Cooperative Catalysis of Pd(OAc)2and a Chiral Phosphoric Acid

Autor:	Wen-Hua Zheng, Kou-Sen Cao
Rok vydání:	2016
Předmět:	chemistry.chemical_compound chemistry Enantioselective synthesis Substrate (chemistry) Organic chemistry chemistry.chemical_element Alcohol General Medicine Optically active Phosphoric acid Desymmetrization Catalysis Palladium
Zdroj:	ChemInform. 47
ISSN:	0931-7597
DOI:	10.1002/chin.201614028
Popis:	The first non-enzymatic desymmetrization of prochiral allenic diols via cooperative binary catalysis of Pd(OAc) 2 and ( R )-STRIP has been reported. This method allows easy access to a series of optically active disubstituted dihydrofurans through palladium mediated 5-endo-trig cyclizations of allenic alcohol with high yields and good to excellent enantioselectivity. A broad substrate scope has been demonstrated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cef83f56d853b07b7a48135d90aa9a6d https://doi.org/10.1002/chin.201614028 Zobrazit plný text záznamu Plný text