In vivoAnti-inflammatory and Antidiabetic Potential of Crude Leaf Extracts ofCanthium coromandelicum(Burm. f.) Alston
| Autor: | Matsyagandha K. Patil, Arju P. Somkuwar, Priyadarshini S. Ekambe, Babasaheb S. Surwase |
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| Rok vydání: | 2016 |
| Předmět: |
Pharmacology
Ethanol Traditional medicine 010405 organic chemistry medicine.drug_class Plant Science Toxicology 01 natural sciences Agricultural and Biological Sciences (miscellaneous) Anti-inflammatory 0104 chemical sciences Carrageenan 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Biochemistry In vivo Alloxan Drug Discovery medicine Acetone Maceration (wine) Methanol |
| Zdroj: | Journal of Biologically Active Products from Nature. 6:195-208 |
| ISSN: | 2231-1874 2231-1866 |
| DOI: | 10.1080/22311866.2016.1222917 |
| Popis: | The present work was carried out to evaluate anti-inflammatory and anti-diabetic activity of different crude leaf extracts of Canthium coromandelicum (Burm. f.) Alston. The crude leaf extracts of C. coromandelicum in different organic solvents like 70% acetone, 70% ethanol and 70% methanol were prepared by maceration and soxhlet method. The anti-inflammatory activity of acetone (AM), ethanol (EM) and methanol (MM) extracts obtained from maceration method was screened by carrageenan induced paw edema model in Wistar rats. Anti-diabetic activity of ethanol (ES) and methanol (MS) extracts obtained from soxhlet method was screened by alloxan induced diabetes in Wistar rats. Further, biochemical parameters and histopathology of liver, kidney and pancreas were also studied. Anti-inflammatory activity of MM and AM extract was found to be statistically significant (P < 0.05) and was shown by decrease in paw edema. EM extract also reduced paw edema but did not show significant result. Anti-diabetic activit... |
| Databáze: | OpenAIRE |
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