Determining The Pressure-Generating Capacity of The Classical and Alternative In Vitro Dissolution Methods Using a Wireless Motility Capsule
| Autor: | Jurij Trontelj, Iztok Grabnar, Igor Legen, Melita Hribar, Ognen Jakasanovski |
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| Rok vydání: | 2018 |
| Předmět: |
Chemistry
In vitro dissolution Gastric motility Pharmaceutical Science Wireless motility capsule Generating capacity 030226 pharmacology & pharmacy Dosage form 03 medical and health sciences 0302 clinical medicine In vivo Drug Discovery 030211 gastroenterology & hepatology Dissolution testing Dissolution Biomedical engineering |
| Zdroj: | Journal of Pharmaceutical Innovation. 13:226-236 |
| ISSN: | 1939-8042 1872-5120 |
| DOI: | 10.1007/s12247-018-9317-1 |
| Popis: | Purpose In vitro dissolution tests are an important tool for prediction of in vivo behavior of pharmaceutical dosage forms. One of the main reasons behind poor in vitro-in vivo correlation is the lack of knowledge about the true in vivo conditions and the failure to replicate them adequately in vitro. The objective of this study was to investigate the conditions during the dissolution testing in terms of their capability to generate the biorelevant pressure values that orally administered dosage forms are exposed to in vivo. |
| Databáze: | OpenAIRE |
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