| Popis: |
This study deals with crystalline nonionic surfactant-water mixtures having lamellar gel structures. The release of an extremely hydrophilic drug (nicotinamide) from mixtures with various water contents was measured and the results compared with Differential Scanning Calorimetry data. It is concluded that the lamellar gel structure fits a simple pore model in which the interlamellar channels behave as pores, the porosity being determined by the free (i. e. unbound) water content, the tortuosity by the orientation of the lamellae. |
