Synthesis and processing of hydrogels for medical applications
| Autor: | F. Redaelli, Filippo Rossi, M. Sorbona |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Ionic bonding 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Tissue engineering chemistry Chemical engineering Covalent bond Polymer chemistry Self-healing hydrogels Drug delivery medicine Molecule Swelling medicine.symptom 0210 nano-technology |
| DOI: | 10.1016/b978-0-08-100262-9.00010-0 |
| Popis: | Hydrogels have received significant attention, especially in the past 30 years, also because of their exceptional promise in biomedical applications, particularly in tissue engineering, as scaffolds for cells growth, and in drug delivery applications, as controlled delivery materials. They are three-dimensional networks of hydrophilic polymers held together by covalent bonds or other cohesive forces such as hydrogen or ionic bonds. They are glassy in the dry state and then, in the presence of solvents, are able to swell while preserving their original shape to form elastic gels. Hydrogels are able to retain a large amount of water in their structure (up to 95% of the total weight); they can either degrade in it by polymer chain degradation reactions (eg, hydrolysis or proteolysis into smaller molecules) and are then called resorbable hydrogels, or they cannot and are then called stable hydrogels. These scaffolds slowly degrade in the physiological environment, leading the growing tissue to replace the former filled site. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|