The potential of BioArena in the study of the formaldehydome

Autor: Ernö Tyihák, Ágnes M. Móricz, György Kátay, Zsuzsa Király-Véghely, Péter G. Ott
Rok vydání: 2005
Předmět:
Zdroj: Journal of Planar Chromatography – Modern TLC. 18:67-72
ISSN: 1789-0993
0933-4173
DOI: 10.1556/jpc.18.2005.1.12
Popis: New results with BioArena as a complex separation and detection (evaluation) system support earlier observations that formaldehyde (HCHO) and its reaction products play a special and crucial role in the effects of antibiotic in general. It has been established that antibiotic-like compounds (e.g. trans-resveratrol, Cu(II) ions) have a duplicate inhibiting effect on pathogen cells as a result of the action of HCHO. HCHO as a key molecule of the formaldehydome participates in series of interactions which can be screened by means of different spectroscopic and chromatographic techniques; accumulation of HCHO and its reaction products in TLC spots is limited, however, so indirect detection is advantageous. In BioArena the planar stationary phase bed after TLC/HPTLC and, mainly, OPLC separation can be used for manifestation of deprivation of HCHO from antibiotic spots, for observation of the duplicate effect of substances with a direct effect, and for demonstration of cell proliferation promotion and retardation.
Databáze: OpenAIRE
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