Effects of a Variety of Endotoxins on Human and Rabbit Platelet Function

Autor:	Nagayama M, Zucker Mb, Beller Fk
Rok vydání:	1971
Předmět:	Chemistry Rabbit (nuclear engineering) Platelet Hematology Function (biology) Cell biology
Zdroj:	Thrombosis and Haemostasis. 26:467-473
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1653699
Popis:	SummaryEndotoxin from Salmonella typhosa or enteritidis, Escherichia coli, or Serratia marcescens caused platelet aggregation, release of platelet-bound 14C-serotonin and development of platelet factor 3 activity when shaken at 37 °C with heparinized platelet-rich plasma (10 units/ml) from rabbits. The relative activity in each test differed for each agent. Endotoxoid only released 14C-serotonin. With human platelet-rich plasma, Salmonella typhosa, E. coli or Serratia marcescens endotoxin failed to induce aggregation or platelet factor 3 activity but caused slow release of platelet-bound 14C-serotonin. Earlier studies showed that endotoxemia in man or endotoxoid injection in rabbits was associated with thrombocytopenia without shock or disseminated intravascular coagulation. This effect appears to correlate with release of 14C-serotonin from platelets in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cec57e370a05f1d346d91836b4da38c6 https://doi.org/10.1055/s-0038-1653699 Zobrazit plný text záznamu