Withaferin A Protects against Primary and Recurrent Tuberculosis by Modulating Mycobacterium-Specific Host Immune Responses

Autor: Anjna Kumari, Isha Pahuja, Kriti Negi, Antara Ghoshal, Suparba Mukopadhyay, Meetu Agarwal, Babu Mathew, Jaswinder Singh Maras, Shivam Chaturvedi, Ashima Bhaskar, Ved Prakash Dwivedi
Rok vydání: 2023
Předmět:
Zdroj: Microbiology Spectrum. 11
ISSN: 2165-0497
DOI: 10.1128/spectrum.00583-23
Popis: Despite being extensive, conventional antituberculosis therapy (ATT) is barely proficient in providing sterile immunity to tuberculosis (TB). Failure to constrain the escalating global TB burden due to the emergence of drug-resistant bacterial strains and immune dampening effects of ATT necessitates adjunct immunotherapeutics for better clinical outcomes.
Databáze: OpenAIRE