Aryl-fused sphingolipids as novel PKC inhibitors with topical antiinflammatory activity

Autor:	Rauckman Barbara S, Brian S. Freed, John J. Tegeler, Gregory H. Merriman, Marie Ortega-Nanos, R. Richard L. Hamer, Luther Hellyer, Ellen S. Kurtz, Steven C. Bailey
Rok vydání:	1995
Předmět:	Allylic rearrangement Sphingosine Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Sphingolipid In vitro chemistry.chemical_compound chemistry Drug Discovery Molecular Medicine Molecular Biology Protein kinase C
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:2477-2482
ISSN:	0960-894X
Popis:	Novel aryl-fused sphingolipids, in which aryl-/heteroaryl-moieties were incorporated into the allylic 4,5,6-positions of sphingosine, were prepared and found to possess good in vitro PKC inhibitory activity. (3-(1-Dodecynyl)phenyl)- and (4- and (5-(1-dodecynyl)-2-thienyl)-2-amino-1,3-propanediols were found to have topical antiinflammatory activity comparable to sphingosine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ceadbec253667ba3e4cc7eca6f7fb763 https://doi.org/10.1016/0960-894x(95)00427-u Zobrazit plný text záznamu Full Text from ScienceDirect