Abstract 487: Immune Response Factors in Patients With Diabetes Mellitus and Acute Coronary Syndrome

Autor:	Svetlana Glova, S. V Shlyk
Rok vydání:	2019
Předmět:	medicine.medical_specialty Acute coronary syndrome Immune system Physiology Immunologic Factors business.industry Internal medicine Diabetes mellitus medicine In patient Cardiology and Cardiovascular Medicine medicine.disease business
Zdroj:	Circulation Research. 125
ISSN:	1524-4571 0009-7330
Popis:	Purpose: To study cardiac remodeling in patients with ACS complicated with DM through analysis of laboratory parameters and echocardiogram. Methods: A total of 67 patients were prospectively enrolled (age range: from 36 to 79 years; average: 60,96 ± 9,22 years) with ACS who were admitted to Emergency Hospital. The patients were divided into 2 groups depending on the presence of DM: 23 patients with DM (age average: 65,09 ± 7,73 years) and 44 without DM (age average: 58,79 ± 9,19 years). Serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high sensitive C reactive protein (hs-CRP), antibodies to LPS General Enterobacteriaceae, antibodies to LPS Re-Glycolipid were tested for all patients. Echocardiograms were obtained on all the patients, interventricular septal thickness (IVSd) and others parameters were measured by taking the mean values of three continuous heartbeat cycles in the expiratory state. All indicators were calculated using the statistics program Statistica, a P-value of < 0,05 was considered statistically significant. Results: There were no significant differences in the prevalence of smoking, family history of CVD, hypertension between groups. No differences were observed in the levels of serum hs-CRP, TC, HDL-C, LDL-C; but TG levels were significantly higher in patients with DM ( 3,16 ± 2,61 mmol/l) than in controls (1,75 ± 1,33 mmol/l, p Conclusion: The data demonstrated, that patients with DM have a greater immune response which correlates with indicators of left ventricular remodeling. The mechanism of the cardiac function impairment, however, has not been clearly explained yet. The role of the immune response in the development of cardiac muscle remodeling is not fully understood. It Is currently considered that these changes may participate in the pathological process of left ventricular remodeling in patients with DM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cea410667a217a4724bf519603061cdc https://doi.org/10.1161/res.125.suppl_1.487 Zobrazit plný text záznamu