Inhibition of human lymphoma cell-line colony formation by lymphocytes from patients with lymphoma and cancer hospital employees

Autor:	U. Ambus, Evan M. Hersh, Giora M. Mavligit, Benjamin Drewinko
Rok vydání:	1976
Předmět:	Cancer Research biology business.industry Melanoma Cancer Hospital employees medicine.disease biology.organism_classification humanities Chinese hamster Lymphoma Oncology Colony formation Antigen Cell culture hemic and lymphatic diseases Immunology medicine business human activities
Zdroj:	Cancer. 37:2929-2937
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(197606)37:6<2929::aid-cncr2820370650>3.0.co;2-p
Popis:	Inhibition of human lymphoma cell-line colony formation (ICF) was induced by peripheral blood lymphocytes (PBL) from patients with lymphoma and apparently healthy cancer hospital personnel. PBL from patients with non-lymphoma neoplasms and from normal blood bank donors did not elicit ICF. ICF was most marked when PBL were cocultivated for 24 hours in a ratio of 1000:I with target lymphoma cells that had been cultured for 24 hours before exposure. No significant ICF was observed when target cells consisted of human neurogenic sarcoma, melanoma, colon adenocarcinoma, or Chinese hamster cells. It is possible that ICF is elicited by PBL sensitized to a cross-reacting antigen present on the membrane of cultured lymphoma cells. This antigen may be synthesized by a transmissible etiologic factor.
Databáze:	OpenAIRE
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