MMP-2/MMP-9 Plasma Level and Brain Expression in Cerebral Amyloid Angiopathy-Associated Hemorrhagic Stroke
| Autor: | Joan Montaner, Pilar Delgado, Carlos A. Molina, Sophie Domingues-Montanari, Jorge Pagola, José Alvarez-Sabín, Mercè Boada, Mar Hernández-Guillamon, Olga Maisterra, Cristina Boada, Alex Rovira, David Rodriguez-Luna, Anna Penalba, Arantxa Ortega-Aznar, Elena Martínez-Sáez |
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| Rok vydání: | 2011 |
| Předmět: |
Intracerebral hemorrhage
Pathology medicine.medical_specialty business.industry General Neuroscience Plasma levels Matrix metalloproteinase medicine.disease Pathology and Forensic Medicine Pathogenesis Brain expression Medicine cardiovascular diseases Neurology (clinical) Cerebral amyloid angiopathy business Stroke Histiocyte |
| Zdroj: | Brain Pathology. 22:133-141 |
| ISSN: | 1015-6305 |
| DOI: | 10.1111/j.1750-3639.2011.00512.x |
| Popis: | Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly. Matrix metalloproteinases (MMPs) have been implicated in blood-brain barrier disruption and ICH pathogenesis. In this study, we determined the levels MMP-2 and MMP-9 in plasma and their brain expression in CAA-associated hemorrhagic stroke. Although MMP-2 and MMP-9 plasma levels did not differ among patients and controls, their brain expression was increased in perihematoma areas of CAA-related hemorrhagic strokes compared with contralateral areas and nonhemorrhagic brains. In addition, MMP-2 reactivity was found in β-amyloid (Aβ)-damaged vessels located far from the acute ICH and in chronic microbleeds. MMP-2 expression was associated to endothelial cells, histiocytes and reactive astrocytes, whereas MMP-9 expression was restricted to inflammatory cells. In summary, MMP-2 expression within and around Aβ-compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding. |
| Databáze: | OpenAIRE |
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