Effects of Aqueous Azadirachta indica Extract on Hepatotoxicity in Rats

Autor:	Hyunjoo Yoon, Ae Son Om, Kyung-Hun Park, Je-Bong Lee, Mi Hye Jeong, Min-Kyoung Paik, Nam-Jun Cho, Beom Seok Han
Rok vydání:	2014
Předmět:	Aqueous solution biology Urinary system General Medicine Azadirachta Pharmacology biology.organism_classification Liver weight chemistry.chemical_compound Azadirachtin chemistry Oral administration Toxicity Liver damage
Zdroj:	Korean Journal of Environmental Agriculture. 33:395-402
ISSN:	2233-4173 1225-3537
DOI:	10.5338/kjea.2014.33.4.395
Popis:	BACKGROUND: Azadirachta indica Extract(AIE) containing azadirachtin as active ingredient have been used worldwide as environment-friendly organic material having pest control properties. However, the extracts prepared with different solvent and from different plant site is very diverse and have different toxicity. METHODS AND RESULTS: In this study, the four week repeated oral dose toxicity test of aqueous AIE in Sprague-Dawley rats was carried out to investigate the toxic effect of liver, main toxicity target organ of AIE. The male and female rats were divided into 4 groups, respectively; control(0 g/Kg bw), low-dose group(0.5 g/Kg bw), middle-dose(1.0 g/Kg bw) and high-dose group(2.0 g/Kg bw). As a results, relative liver weight increased with dose-dependent of AIE(p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ce7fd863daa29f7e3bb17a98d16f8e0d https://doi.org/10.5338/kjea.2014.33.4.395 Zobrazit plný text záznamu