Synthesis of substituted dibenzophospholes. Part 1
| Autor: | Robin T. Gray, John Cornforth, Rita H. Cornforth |
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| Rok vydání: | 1982 |
| Předmět: | |
| Zdroj: | Journal of the Chemical Society, Perkin Transactions 1. :2289 |
| ISSN: | 1364-5463 0300-922X |
| Popis: | Approaches to the synthesis of 4,6-diaryl-5-hydroxydibenzophosphole 5-oxides are described. 3,5,7-Trihydroxydibenzophosphole 5-oxide and several of its O-substituted derivatives were made either from 5-hydroxydibenzophosphole 5-oxide (convenient preparation described) by dinitration, reduction and tetrazotization or from 2,2′-dibromo-4,4′-dimethoxybiphenyl via lithiation and reaction with dichloromorpholinophosphine with subsequent oxidation. 3,5,7-Trihydroxydibenzophosphole 5-oxide could be selectively blocked in the 2,8-positions by methyl groups generated via a Mannish reaction. The bis-2-iodobenzyl ethers of 3,7-dihydroxy-5-methoxydibenzophosphole 5-oxide and of its 2,8-dimethyl derivative were cyclized by photolysis to form 4,6-diaryl derivatives in poor yield. |
| Databáze: | OpenAIRE |
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