Intravenous lipid emulsion infusion in acute intoxication with fenitrothion

Autor:	Maya Radeva, Petko Marinov, Gabriela Kehayova, Snezha Zlateva, Dobri Ivanov, Simeonka Dimitrova, Stanila Stoeva
Rok vydání:	2018
Předmět:	Intravenous lipid emulsion business.industry Glasgow Coma Scale Acute intoxication Clinical toxicology Tachypnea Acute toxicity Fenitrothion chemistry.chemical_compound chemistry Anesthesia Total dose medicine medicine.symptom business
Zdroj:	Scripta Scientifica Pharmaceutica. 5:47
ISSN:	2367-5500 2367-6000
DOI:	10.14748/ssp.v1i1.5108
Popis:	Acute intoxications with organophosphorus pesticides (OPs) are a challenge for the clinical toxicology, because they are common, severe and with high lethality. Most OPs are lipophilic. In recent years, intravenous lipid emulsion (ILE) has been successfully used to treat acute poisoning with lipophilic xenobiotics. A clinical case of a 64-year-old male hospitalized after oral intake of 50 ml of fenitrothion is reported. He had been hospitalized with tachypnea and depressed consciousness - 8 by Glasgow coma scale (GCS). Standardized for this type of intoxication treatment was initiated. On the 3rd hour treatment with Intralipid 20% was started, with a bolus dose of 1.5 ml/kg followed by infusion at a rate of 0.25 ml/kg/min to a total dose of 1000 ml. At the 16th hour consciousness was restored to GCS-15. In severe FTO intoxications ILE can be used as an additional method of controlling cardiotoxic and neurotoxic effects.
Databáze:	OpenAIRE
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