New Approaches to Adjuvant Therapy of Colorectal Carcinoma Including Current German Activities
| Autor: | P. Diezler, G. Hartung, W. Queißer, E. Hagmüller |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Colorectal cancer business.industry medicine.medical_treatment Rectum Combination chemotherapy Hematology medicine.disease law.invention Folinic acid medicine.anatomical_structure Randomized controlled trial law Multicenter trial Internal medicine medicine Adjuvant therapy business Adjuvant medicine.drug |
| Zdroj: | Oncology Research and Treatment. 16:416-424 |
| ISSN: | 2296-5262 2296-5270 |
| DOI: | 10.1159/000218300 |
| Popis: | In this review new approaches to adjuvant therapy of colon and rectum carcinomas are reported. Early trials in the 70s using 5-fluorouracil and other monotherapies did not show any advantage for prognosis. The use of combination chemotherapy (e.g. 5-fluorouracil + methyl-CCNU) in several prospective trials suggested a considerable increase of late neoplasia. A statistically significant prolongation of recurrence-free survival and overall survival for patients with high-risk colon carcinoma (Dukes C) was first seen by combination of 5-fluorouracil with levamisole. Data of a first multicenter trial were recently confirmed by a larger series. For rectum carcinoma postoperative radiation therapy, effective for reduction of local recurrences, was included in adjuvant chemotherapy in several studies suggesting a statistically significant advantage of recurrence and overall survival. Recent data and analyses indicate that the combination of 5-fluorouracil and folinic acid, which shows high efficacy in advanced stages of colorectal carcinoma, is effective in the adjuvant setting too. During 1992/1993 in Germany five multicenter, prospective randomized trials were activated to clarify further details of this new prophylactic treatmenl possibility for colorectal carcinoma. |
| Databáze: | OpenAIRE |
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