Composition of Essential Oil from Tagetes minuta and its Cytotoxic, Antioxidant and Antimicrobial Activities
| Autor: | Ali Gamal Al-kaf, Ludger A. Wessjohann, Saeed S. Al-Sokari, William N. Setzer, Norbert Arnold, Nasser A. Awadh Ali, Gabrielle M. Hill, Farukh Sharopov |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Tagetes minuta Limonene Antioxidant biology Chemistry DPPH medicine.medical_treatment Plant Science General Medicine Antimicrobial biology.organism_classification food.food law.invention chemistry.chemical_compound food Complementary and alternative medicine Tagetes law Drug Discovery Botany medicine Food science Candida albicans Essential oil |
| Zdroj: | Natural Product Communications. 9:1934578X1400900 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | The essential oil from the leaves of Tagetes minuta L., growing wild in Yemen, was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. A total of 28 compounds were identified representing 74.2% of total oil composition. Major components of the essential oil were ( Z)-ocimenone (15.9%), ( E)-ocimenone (34.8%), ( Z)-β-ocimene (8.3%), limonene (2.3%), ( Z)-tagetone (1.8%), dihydrotagetone (1.4%) and an unidentified dimethylvinylketone derivative (20.6%). The oil showed moderate cytotoxic activity against MCF-7 breast tumor cells, with an IC50 of 54.7 ± 6.2 μg/mL. In the DPPH radical scavenging assay, T. minuta oil showed potent antiradical activity with an IC50 value of 36 μg/mL. Antimicrobial activity was also investigated on several microorganisms, and the essential oil exhibited high activity against methicillin-resistant Staphylococcus aureus (MRSA) with an inhibition zone of 23 mm. It also exhibited remarkable antifungal activity against Candida albicans with an inhibition zone of 26 mm. |
| Databáze: | OpenAIRE |
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