Prevention of relapse in patients with chronic non-A, non-B/C hepatitis who respond to alpha-interferon. A controlled multicenter trial of low-dose maintenance therapy
| Autor: | Pierre Michel, A. Valla, Christian Trepo, Paul Calès, Yves Le Charpentier, J.J. Voigt, Catherine Buffet, Gérard Babany, Marc Bourlière, Denis Ouzan, Claude Eugène, Jean-Didier Grangé, Jean-Louis Payen, Pierre Opolon, Eric Bercoff, Jacques Denis, P. Couzigou, Monique Fabre, Daniel Fischer, Jean-Claude Paris, Dominique Valla, Michel Veyrac, Victor-Georges Levy |
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| Rok vydání: | 1994 |
| Předmět: |
Hepatitis
medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Alpha interferon Hepatitis C medicine.disease Gastroenterology Surgery law.invention Maintenance therapy Randomized controlled trial law Liver biopsy Internal medicine Multicenter trial medicine business Interferon alfa medicine.drug |
| Zdroj: | Journal of Hepatology. 21:774-778 |
| ISSN: | 0168-8278 |
| Popis: | We tested the efficacy of maintenance treatment with alpha-2a interferon, 1 megaunit thrice weekly for 6 months, in preventing relapse of non-A, non-B/C hepatitis in remission after treatment with alpha interferon given thrice weekly according to the following dose schedule: 3 megaunits for 3 months, 2 megaunits for 2 months and 1 megaunit for 1 month. Fifty-three patients with hepatitis C in remission were randomly allocated to a treatment group ( n =26) or a control group ( n =27). A relapse (aminotransferase activity >1.5 times the upper limit of normal) occurred in 46% of the controls and 35% of the treated patients (NS). Maintenance treatment had no significant influence on histopathologic changes evaluated by three independent observers: in both groups the overall score for histologic lesions improved between the initiation of interferon therapy and the end of the study. We conclude that relapses in patients with non-A, non-B/C hepatitis in remission after treatment with alpha interferon at tapering doses are not prevented by maintenance therapy with low-dose alpha interferon. |
| Databáze: | OpenAIRE |
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