Post-heparin plasma lipoprotein and hepatic lipases
| Autor: | Moti L. Kashyap, P.J. Kinnunen, K. Robinson, Timo Kuusi, C.J. Glueck, Marja-Riitta Taskinen, L.S. Srivastava, G. Perisutti, B.A. Hynd |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Lipoprotein lipase Triglyceride Catabolism Cholesterol nutritional and metabolic diseases Heparin medicine.disease chemistry.chemical_compound Endocrinology High-density lipoprotein chemistry Internal medicine Hyperlipidemia medicine lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine medicine.drug Lipoprotein |
| Zdroj: | Atherosclerosis. 37:247-256 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(80)90010-6 |
| Popis: | Post-heparin lipoprotein lipase (PH-LPL)-high density lipoprotein cholesterol (HDL-C) interrelationships were assessed in 9 subjects with documented familial hyperalphalipoproteinemia (FHA) and in 8 controls to focus on potential biochemical etiologies of FHA and relationships of HDL-C to triglyceride hydrolysis and PH-LPL. FHA subjects had mean HDL-C and HDL 2 -C levels > twice controls; their PH-LPL levels (X ± SEM) (3.14 ± 2.3 μmol FFA/h/ ml) were also > twice that of controls (15.0 ± 1.6) ( P P > 0.1). For all subjects (FHA and controls) PH-LPL was positively correlated with HDL-C (r = 0.79, P 2 -C (r = 0.90, P 3 -C (r = −0.02). There were no significant PH-HL and HDL-C interrelationships, P > 0.1. The amount of apo CII (the primary activator of PH-LPL) in HDL 2 was greater in the FHA (X ± SEM) (16.1 ± 2.5 μg/ml plasma) than in control subjects (4.7 ± 0.9, P 2 apo CII and both PH-LPL (r = 0.79, P 2 -C (r = 0.80, P 2 protein was higher in FHA than control subjects (X ± SEM) (1.2 ± 0.3% vs 0.5 ± 0.2%, P 3 protein was similar in FHA and control subjects. We postulate that increased turnover rate of triglyceride-rich lipoproteins due to high LPL activity may be an important factor leading to the elevation of HDL-C in FHA. The highly significant positive correlation between HDL 2 -C and PH-LPL provides strong clinical evidence for the theory that HDL 2 is formed during the hydrolysis of triglycceride-rich lipoproteins. The high concentration of HDL 2 apo CII in FHA subjects may be caused by increased catabolism of triglyceride-rich lipoproteins in the presence of high endothelial LPL, with transfer of apo CII from very low to high density lipoproteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|