Ultraviolet B–Induced Maturation of CD11b-Type Langerin− Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin
| Autor: | Hiroaki Shime, Shimon Sakaguchi, Naganari Ohkura, Akiko Nishioka, Saori Kasuya, Tsuneyasu Kaisho, Akimichi Morita, Mizuyu Odanaka, Hiroaki Hemmi, Sayuri Yamazaki, Masaki Imai, Dieter Riethmacher |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CD86 integumentary system biology Langerin Cellular differentiation Immunology FOXP3 chemical and pharmacologic phenomena hemic and immune systems medicine.disease_cause Autoimmunity Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Integrin alpha M Antigen biology.protein medicine Immunology and Allergy CD80 030215 immunology |
| Zdroj: | The Journal of Immunology. 200:119-129 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1701056 |
| Popis: | Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin− DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin− DCs upregulated surface CD86 expression, induced proliferation of Foxp3+ regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin− DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity. |
| Databáze: | OpenAIRE |
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