Relation between configuration and n-chgline blocking activity of 4-vinylethynyl- and 4-butyl-substituted decahydro-4-quinolinols

Autor:	L. I. Ukhova, A. P. Marochkin, G. V. Bludova, B. B. Kuz'mitskii, A. A. Akhrem
Rok vydání:	1972
Předmět:	chemistry.chemical_compound Nitrogen atom Chemistry Blocking (radio) Stereochemistry Substituent General Chemistry Receptor Acute toxicity Methyl group
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 21:2715-2718
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00849848
Popis:	1. The investigated 4-vinylethynyl- and 4-butyldecahydro-4-quinolinols exert a blocking action on the central n-choline receptors; the blocking action is determined not only by the character of the nitrogen atom and of the substituents in the 4-position, but also by their conformation. 2. The acute toxicity of the 4-vinylethynyl and 4-butyl derivatives of the decahydro-4-quinolinols is relatively high and varies only slightly as a function of the configuration of the methyl group at C2 and the substituent at C4.
Databáze:	OpenAIRE
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