Convergent evolution of mevalonate pathway in Inonotus obliquus and Betula pendula
| Autor: | Niko Silvan, Pia Laine, Uwe Richter, Kirk Overmyer, Jarkko Salojärvi, Nina Sipari, Guleycan Lutfullahoglu-Bal, Pezhman Safdari, Tytti Sarjala, Jaakko Kangasjärvi, Sitaram Rajaraman, Omid Safronov, Olli-Pekka Smolander, Maya Wilkens, Brendan J. Battersby, Lars Paulin, Jenna Lihavainen, Petri Auvinen |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Genetics 0303 health sciences Genome evolution Contig Hymenochaetaceae Biology biology.organism_classification 01 natural sciences Genome 3. Good health 03 medical and health sciences Convergent evolution Gene duplication Inonotus obliquus Mevalonate pathway 030304 developmental biology 010606 plant biology & botany |
| Popis: | Inonotus obliquus, Chaga mushroom, is a fungal species from Hymenochaetaceae family (Basidiomycota) which has been widely used for traditional medicine in Europe and Asia. Here, chaga genome was sequenced using Pacbio sequencing into a 50.7Mbp assembly consisting of 301 primary contigs with an N50 value of 375 kbp. Genome evolution analyses revealed a lineage-specific whole genome duplication event and an expansion of Cytochrome P450 superfamily. Fungal biosynthetic clusters were enriched for tandemly duplicated genes, suggesting that biosynthetic pathway evolution has proceeded through small-scale duplications. Metabolomic fingerprinting confirmed a highly complex terpene biosynthesis chemistry when compared against related fungal species lacking the genome duplication event. |
| Databáze: | OpenAIRE |
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