| Popis: |
The use of chemotherapy in addition to radiation has unquestionably improved outcomes in both small cell and non-small cell lung cancer. However, as in advanced disease, a plateau in efficacy has been reached. Over the past several decades numerous receptors and pathways responsible for normal cellular growth, maintenance and development have been identified. Derangements of these pathways frequently result in cancer, perpetuate cancer or result in resistance to treatment with chemotherapy and/or radiation. New agents targeting these pathways are now becoming available. Many of these have the potential to potentiate existing agents and/or radiation. In addition, radiation can itself be targeted by coupling radioisotopes to a moiety that will bind with receptors that are aberrantly expressed in cancer. |
