Synthesis of Acyl Derivatives of Prolyl-leucinamides

Autor:	V. A. Knizhnikov, L. A. Popova, D. V. Kievitskaya, V. A. Haidukevich
Rok vydání:	2020
Předmět:	chemistry.chemical_compound Benzoyl chloride Benzylamine chemistry Acetyl chloride Morpholine Organic Chemistry Condensation Leucine Triethylamine Medicinal chemistry
Zdroj:	Russian Journal of Organic Chemistry. 56:82-89
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428020010145
Popis:	Synthetic routes to prolyl-leucinamide, N-benzyl(prolyl)leucinamide, and N-(prolyl-leucyl)morpholine were proposed. Treatment of these compounds with benzoyl chloride or acetyl chloride in the presence of triethylamine afforded the corresponding (N-acylprolyl)leucinamides. Acyl derivatives of N-benzyl(prolyl)-leucinamide, and N-(prolyl-leucyl)morpholine were also synthesized by condensation of (N-benzoylprolyl)-leucine or (N-acetylprolyl)leucine with benzylamine or morpholine in the presence of N, N′-dicyclohexyl-carbodiimide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ce30498d784b49b657c5af52fde8ddff https://doi.org/10.1134/s1070428020010145 Zobrazit plný text záznamu Plný text ve formátu PDF