959 EFFICACY OF BOVINE LEUKOCYTE DIALYSATES CONTAINING TRANSFER FACTOR (TF) IN THE THERAPY OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
| Autor: | Phillip Larussa, William Borkowsky, H. Sherwood Lawrence, Phillip Klesius, Shelley Gordon |
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| Rok vydání: | 1985 |
| Předmět: | |
| Zdroj: | Pediatric Research. 19:270A-270A |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198504000-00989 |
| Popis: | Three patients with AIDS and chronic diarrhea due to cryptosporidia were treated with weekly oral doses of bovine TF (107 leukocyte equivalents/kg) prepared from lymph nodes of calves immunized with cryptosporidia oocysts. All the patients demonstrated a resolution of their diarrhea and a cessation of oocyst excretion within 6 weeks of therapy. One patient relapsed upon cessation of TF therapy, while the other two remained cryptosporidia free for the duration of their observation. One of these individuals was subsequently started on weekly bovine TF therapy derived from calves immunized with pooled AIDS lymphoid cells and marker proteins diphtheria and tetanus toxoids (DT & TT) in complete Freund's adjuvant. Although there have been no qualitative changes in his T-cell phenotypes after 4 months of therapy, the patient has acquired in vitro proliferative responses to DT, TT and tuberculin. In addition, he has acquired delayed type skin responses to DT, TT and streptokinase - streptodornase. Concommitant with his immunologic reactivity, the patient has remained infection free during TF therapy. Our experience with bovine TF immunotherapy suggests that (1) some degree of immunologic reconstitution is possible in patients with AIDS, and (2) cryptosporidiosis may respond to bovine TF administration. |
| Databáze: | OpenAIRE |
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