ChemInform Abstract: The Partial Reduction of Heterocycles: An Alternative to the Birch Reduction

Autor:	Rick P. C. Cousins, Rakesh R. Harji, Timothy J. Donohoe
Rok vydání:	2010
Předmět:	Birch reduction Chemistry General Medicine Alkylation Combinatorial chemistry Chloride Redox Acylation Solvent chemistry.chemical_compound medicine Amine gas treating medicine.drug Naphthalene
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200021060
Popis:	The partial reduction of a series of heterocycles in THF is described. By adding amine 3 as a proton source and naphthalene as an electron carrier, we were able to produce reductively alkylated pyrrolines and dihydrofurans in moderate to good yields. This reaction does not require liquid ammonia as a solvent, which may have interesting ramifications for large-scale synthesis. Moreover, we were also able to quench the reduction reactions with an acid chloride so performing a reductive acylation reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ce276f3e3c83d3bcf6a9b5e641afef7e https://doi.org/10.1002/chin.200021060 Zobrazit plný text záznamu Plný text