ISLET ALLOGRAFT, ISLET XENOGRAFT, AND SKIN ALLOGRAFT SURVIVAL IN CD8
| Autor: | O. Smithies, Niraj M. Desai, James I. Kim, Ali Naji, Beverly H. Koller, Hamid Bassiri, James F. Markmann, Clyde F. Barker |
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| Rok vydání: | 1993 |
| Předmět: |
Transplantation
geography geography.geographical_feature_category biology Beta-2 microglobulin business.industry T cell chemical and pharmacologic phenomena T lymphocyte Islet surgical procedures operative medicine.anatomical_structure MHC class I Cancer research biology.protein Medicine Cytotoxic T cell business CD8 |
| Zdroj: | Transplantation. 55:718-721 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-199304000-00006 |
| Popis: | Despite extensive study, the immunologic mechanisms mediating allograft rejection have not been completely defined. In the current study, we evaluated the T cell subsets important in islet allograft, skin allograft, and islet xenograft rejection using a genetically engineered line of mice deficient in β 2 -microglobulin expression. Because these mice lack cell surface MHC class I expression, they are deficient in T cells of the CD8 subset (class I-restricted cytotoxic T cells). Pancreatic islet allografts transplanted to CD8 + T cell-deficient recipients showed prolonged survival compared with controls. No prolongation was observed in the survival of pancreatic islet xenografts or in the survival of skin allografts transplanted to the CD8 + T cell-deficient hosts |
| Databáze: | OpenAIRE |
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