ChemInform Abstract: Practical Route to a New Class of LTD4 Receptor Antagonists

Autor:	Thomas R. Verhoeven, Anthony O. King, Paul J. Reider, Paul Davis, Edward G. Corley, James D. Carroll, Xiang Yi Bin, Marc Labelle, Robert Zamboni, Jacques Yves Gauthier, Robert D. Larsen
Rok vydání:	2010
Předmět:	Reduction (complexity) chemistry.chemical_compound LTD4 receptor Chemistry Stereochemistry Heck reaction Moiety Selective reduction General Medicine Alkylation Enone
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199637198
Popis:	A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen−Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ce0cdf46ac53dac10241aed8461e9b82 https://doi.org/10.1002/chin.199637198 Zobrazit plný text záznamu Plný text