The effect of motilin on the rectum in healthy volunteers
| Autor: | M. F. Oppenhuizen-Duinker, H. C. Schoemaker, R. Jones, Ad A.M. Masclee, A. D. Van Haarst, Ingrid M C Kamerling, J. Burggraaf, Adam F. Cohen, Hartmut Heinzerling, Izak Biemond |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
medicine.medical_specialty Gastrointestinal agent business.industry digestive oral and skin physiology Rectum Radioimmunoassay Placebo Gastroenterology Crossover study Barostat Confidence interval Motilin medicine.anatomical_structure Endocrinology Internal medicine medicine Pharmacology (medical) business hormones hormone substitutes and hormone antagonists |
| Zdroj: | British Journal of Clinical Pharmacology. 55:538-543 |
| ISSN: | 0306-5251 |
| Popis: | Aims The role of motilin in the regulation of upper gastrointestinal (GI) motility is well defined. However, little is known about the effects on the distal GI tract. To investigate the effect of exogenous motilin on rectal function, barostat measurements in the rectum were performed and lower abdominal symptoms were scored. Methods Eight fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min in a double-blind, randomized, cross-over design. Rectum volume was measured with a barostat device during constant pressure and during isobaric distensions. Lower abdominal symptoms were scored by visual analogue scales. Plasma motilin concentrations were measured by radioimmunoassay. Results Baseline rectum volumes were similar between treatments: 185 ± 62 mL (motilin) and 136 ± 41 mL (placebo). During the constant pressure procedure, motilin increased rectum volume [area under the effect curve (AUEC)] by 6%[95% confidence interval (CI) −3, 16] of baseline, compared with placebo. During isobaric distensions motilin increased rectum volume (AUEC) by 43 mL (95% CI 0.4, 85; P |
| Databáze: | OpenAIRE |
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