STIFFENED ERYTHROCYTES IN POLYCYTHEMIA OF CYANOTIC CONGENITAL HEART DISEASE (CCHD)
| Autor: | Nancy B. McWilliams, Charles L. Johnston, Carolyn M. McCue, Joyce C. Haggins, Harold M. Maurer |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
business.industry Cyanotic congenital heart disease Hydrostatic pressure Polycarbonate filter Hyperviscosity Surgery Hemorrhagic complication Internal medicine Blood Hyperviscosity Pediatrics Perinatology and Child Health Cardiology medicine Increased rbc business Thrombotic complication circulatory and respiratory physiology |
| Zdroj: | Pediatric Research. 11:476-476 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-197704000-00637 |
| Popis: | As the hct rises above 60% in CCHD, there is an increased threat of thrombotic and hemorrhagic complications due to blood hyperviscosity. Hyperviscosity has been attributed to increased RBC mass. Since RBC deformability is a determinant of viscosity and flow at high hcts, we studied RBC deformability in 22 children with polycythemic CCHD and in 10 controls, using a Ciltration system. Filterability is a function of cell deformability. Washed RBC's resuspended in Ringer's lactate-albumin solution were passed through a 3u polycarbonate filter using hydrostatic pressure (at 25°C), and flow velocity was calculated (ul/sec). Controls had a mean hct of 41%± 2, mean MCV of 87f1± 2, and mean RBC flow velocity of 5.0 ul/sec±.7. Children with CCHD were divided into 2 groups: 10 patients with hcts between 50-60% (mean 53±1), and 12 patients with hcts >60% (range 63-74%, mean 67%±1). Mean flow velocity (3.4ul/sec±2) in the group with hcts >60% was significantly (p=.05) reduced as compared to controls and the |
| Databáze: | OpenAIRE |
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