The effect of omeprazole on gastro-oesophageal reflux and symptoms during strenuous exercise

Autor:	H. P. F. Peters, Eduard Bol, W. L. Mosterd, W. R. de Vries, A. F. C. C. De Kort, Louis M. A. Akkermans, H. van Krevelen, G. P. van Berge Henegouwen
Rok vydání:	1999
Předmět:	medicine.medical_specialty Hepatology business.industry medicine.drug_class digestive oral and skin physiology Gastroenterology Reflux Proton-pump inhibitor Heartburn Regurgitation (circulation) Chest pain Placebo Crossover study digestive system diseases Surgery Anesthesia medicine Pharmacology (medical) medicine.symptom business Omeprazole medicine.drug
Zdroj:	Alimentary Pharmacology & Therapeutics. 13:1015-1022
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.1999.00579.x
Popis:	Background : Strenuous exercise exacerbates gastro-oesophageal reflux and symptoms and this may be diminished by antisecretory medication with omeprazole. Methods : Fourteen well-trained athletes (13 men, one woman), who indicated suffering from either heartburn, regurgitation or chest pain during competition running, performed two experimental trials at 2-week intervals using a randomized, double-blind, placebo-controlled crossover design. During the 6 days preceding the trial and on the trial day itself either 20 mg of omeprazole or a placebo was administered. Two hours after a low-fat breakfast and 1 h after the last study dose, the trial started with five successive 50-min periods: rest, three running periods on a treadmill, and recovery. Reflux (percentage time and number of periods oesophageal pH
Databáze:	OpenAIRE
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