PBSCT is associated with poorer survival and increased chronic GvHD than BMT in Japanese paediatric patients with acute leukaemia and an HLA-matched sibling donor
| Autor: | Hiromasa Yabe, Shun Ichi Kato, Yoshiyuki Takahashi, Atsushi Ogawa, Toshiyuki Kitoh, Hideaki Ohta, Yoshiko Atsuta, Souichi Adachi, Koji Kato, Katsuyoshi Koh, Yoji Sasahara, Aki Shinzato, Ken Tabuchi, Jiro Inagaki, Masami Inoue, Hisato Kigasawa |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty Allogeneic transplantation business.industry Retrospective cohort study Hematology Disease medicine.disease Surgery Transplantation Leukemia surgical procedures operative medicine.anatomical_structure hemic and lymphatic diseases Internal medicine Pediatrics Perinatology and Child Health Medicine Cumulative incidence Bone marrow Stem cell business |
| Zdroj: | Pediatric Blood & Cancer. 60:1513-1519 |
| ISSN: | 1545-5009 |
| Popis: | Background Peripheral blood stem cells (PBSC) may be used as an alternative to bone marrow (BM) for allogeneic transplantation. Since peripheral blood stem cell bank from unrelated volunteer donor has been started in Japan, use of PBSC allografts may be increased. Therefore we surveyed the outcomes of Japanese leukemia children after PBSC and BM transplantation. Procedure This retrospective study compared the outcomes of 661 children (0–18 years) with acute lymphoblastic leukaemia (ALL) or acute myeloid leukaemia (AML) who received their first allogeneic peripheral blood stem cell transplantation (PBSCT; n = 90) or bone marrow transplantation (BMT; n = 571) from HLA-matched siblings between January 1996 and December 2007. Result Neutrophil recovery was faster after PBSCT than after BMT (ALL: P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text