Studies on mutagen-sensitive strains of Drosophila melanogaster

Autor:	G.B. Vegt, W. Ferro
Rok vydání:	1987
Předmět:	Genetics Mutation DNA damage Health Toxicology and Mutagenesis Mutant Mutagen Biology medicine.disease_cause Molecular biology chemistry.chemical_compound chemistry Cell culture medicine Radiation Induced DNA Damage Photolyase Molecular Biology DNA
Zdroj:	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 177:95-100
ISSN:	0027-5107
DOI:	10.1016/0027-5107(87)90025-x
Popis:	The repair of X-ray-induced DNA lesions in repair-deficient mutant strains was studied as a way of investigating the mechanism of the induction of genetic damage. Genetic effects on the recovery of X-ray-induced damage by the repair-deficient strains ebony (photoreactivation repair-deficient) and mus(1)101D1 (post-replication repair-deficient) were interpreted as impaired repair of single- and double-strand DNA breaks. We investigated the repair of X-ray-induced DNA breaks and alkaline-labile sites in primary cells cultures of ebony and mus(1)101D1 and in cultures of their control strains. No significant differences were found the repair rates in the mutants and control strains. This indicates that the genetic effects of these mutants are not due to an impaired rate of repair of DNA breaks.
Databáze:	OpenAIRE
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