Overlap syndrome: association of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren
| Autor: | T. V. Polivanova, V. A. Vshivkov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 67:54-59 |
| ISSN: | 2500-2228 1027-4065 |
| DOI: | 10.21508/1027-4065-2022-67-4-54-59 |
| Popis: | The combination of gastroesophageal reflux disease with dyspepsia syndrome in a particular patient is designated as overlap syndrome, the problem of which is widely discussed.Purpose. To study the regional characteristics of the association of gastroesophageal reflux disease with dyspepsia syndrome in Siberian schoolchildren with gastrointestinal complaints.Materials and methods. Schoolchildren of Siberia 7–17 years old were examined: in Tyva (1535 children), Buryatia (790 children), and Evenkia (1369 children). Information about gastroenterological complaints was collected. By the method of random selection, children with gastroenterological complaints underwent esophagogastroduodenoscopy in Tyva, 283 children, in Buryatia, 110 children, and in Evenkia, 205 children. The studies were approved by the ethics committee and the consent of the patients and their parents was obtained.Results. In Siberian schoolchildren, the prevalence of GERD and DS overlap syndrome was 4.7%. In Tyva, the overlap of gastroesophageal reflux disease with dyspepsia syndrome in schoolchildren was found most often: 6.9%, which was significantly higher than in Buryatia (3.7%; p = 0.0016) and in Evenkia (2.8%; p = 0.0001). regional features have been established in the distribution of clinical variants of dyspepsia associated with gastroesophageal reflux disease in schoolchildren. So, in the children of Buryatia and Evenkia, the dominant association was gastroesophageal reflux disease with postprandial distress syndrome, in Tyva — with epigastric pain. Among endoscopically examined schoolchildren in the absence of erosive and ulcerative diseases, similar associative relationships between gastroesophageal reflux disease with dyspepsia syndrome and its clinical variants were determined.Conclusion. Regional differences were established, both in the prevalence of overlap syndrome and the severity of the association of gastroesophageal reflux disease with variants of the clinical course of dyspepsia syndrome. It is not unlikely that overlapping disorders are united by a single leading pathomechanism in their formation. |
| Databáze: | OpenAIRE |
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