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Chronic rhinosinusitis (CRS), a common upper airway disease, is characterized by inflammation of the nasal cavity and paranasal sinuses lasting for 12 consecutive weeks. CRS is often accompanied by some nasal symptoms, such as nasal drainage, congestion, and anosmia, which leads to a dramatic decrease in the patient's quality of life. Studies have shown that patients with CRS may have certain comorbidities and the most common one is bronchial asthma (BA). BA is a chronic allergic inflammatory disease of the lower airways characterized by reversible airflow obstruction and bronchial hyperresponsiveness. The typical symptoms of asthma are chest tightness, dyspnea, cough, and wheezing. Presently, CRS and BA are considered in the context of the unified airway theory, which describes the upper and lower airways as a single functional unit. The relationship between CRS and BA has been widely studied. Studies have shown that rhinosinusitis played a role in triggering asthma attacks, and the symptoms of asthma were observed to relieve after medical or surgical treatment of rhinosinusitis. What’s more, patients with CRS were more likely to develop asthma. However, a recent report found that there was no correlation between CT-documented sinonasal involvement and asthma severity. Besides, the CT findings of Bresciani et al indicated that CRS was not associated with asthma severity. Although the relationship between CRS and asthma has been demonstrated in a lot of studies, there still exists inconsistency. Besides, little is known about the relationship between CRS and the severity of asthma. Hence, we plan to perform a meta-analysis to figure out the relationship between CRS and asthma as well as its severity. |
