Penitremones A–C, Penicillium metabolites containing an oxidised penitrem carbon skeleton giving insight into structure–tremorgenic relationships

Autor:	Eric S. Waight, Richard N. Sheppard, Peter G. Mantle, Jyotigna T. Naik
Rok vydání:	1995
Předmět:	biology Stereochemistry Metabolite Carbon skeleton biology.organism_classification Into-structure chemistry.chemical_compound 13c nmr spectroscopy Penitrem E chemistry Penicillium Penitrem A Organic chemistry Mycotoxin
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :1121-1125
ISSN:	1364-5463 0300-922X
Popis:	A new group of microbial metabolites, designated penitremones A–C, have been characterised by mass spectrometry and 1H and 13C NMR spectroscopy as 10-keto, 11,33-dihydro-variants of the penitrem indole-isoprenoid skeleton. The principal metabolite penitremone A, produced with penitrem A by a Penicillium sp., is an isomer of penitrem E and was also similarly tremorgenic. Reduction of the carbonyl of penitremones A and B with NaHB4 altered tremorgenic activity, thereby indicating potential for new insights into structure–activity relationships in tremorgenic mycotoxins, particularly with respect to neurological disorders in agricultural ruminants caused by the related keto-alkaloid lolitrem B.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cdc7ad40737c308a4544e2c31eddfa15 https://doi.org/10.1039/p19950001121 Zobrazit plný text záznamu