Interleukin‐33 in pulmonary arterial hypertension: a role in disease pathogenesis? (1090.4)
| Autor: | Sandra Lombardi, Justin Dumouchel, Jinghong Li, Timothy D. Bigby, Fiona Murray, Nick H. Kim, Nakon Aroonsakool, Dominic Titone, David Poch |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Lung business.industry medicine.medical_treatment medicine.disease Biochemistry Connective tissue disease Peripheral blood mononuclear cell Interleukin 33 medicine.anatomical_structure Endocrinology Cytokine Pathophysiology of hypertension Internal medicine medicine.artery Pulmonary artery Genetics medicine Receptor business Molecular Biology Biotechnology |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary vascular resistance that leads to right ventricular failure. PAH can be a primary disease (idiopathic, IPAH) or secondary to conditions such as connective tissue disease. Interleukin-33 (IL-33), which is the ligand for the ST2 receptor, is a cytokine that acts as an alarmin. Since PAH is associated with the infiltration of inflammatory cells and increased cytokines, we aimed to investigate the role of IL-33 in PAH. Using an IL-33 ELISA we found that IL-33 is increased in the serum of PAH patients, in particular IPAH [1798 +/-846 pg/ml (n=6) vs. 24 +/- 13 pg/ml (n=6), p |
| Databáze: | OpenAIRE |
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