Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

Autor:	Z. A. Khushbaktova, M G Klinnikova, N.V. Tursunova, Yu. V. Tornuev, Vladimir Nikolaevich Syrov
Rok vydání:	2021
Předmět:	Hepatitis Toxic hepatitis Cytochrome biology General Medicine Metabolism Monooxygenase Nitrite reductase Sesquiterpene medicine.disease General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Biochemistry chemistry biology.protein medicine medicine.symptom Xenobiotic
Zdroj:	Bulletin of Experimental Biology and Medicine. 172:133-136
ISSN:	1573-8221 0007-4888
Popis:	We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes of rats with toxic CCl4-induced hepatitis after a 14-day course of sesquiterpene lactones from Artemisia leucodes (10 mg/kg). It was found that toxic hepatitis was associated with significant inhibition of NADPH-cytochrome c-reductase, benzo(a)pyrene hydroxylase, and NADPH-diaphorase, reduced cytochrome P-450 content, and enhanced induction of nitrate/nitrite reductase with accumulation of NO metabolites in the liver. Administration of sesquiterpene lactones stimulated activity of the studied components of the cytochrome P-450 system and promoted recovery of the NOergic system components; the effects were most pronounced in 7 and 14 days after treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cdbdedc0addff65127a33dc2dc65da5d https://doi.org/10.1007/s10517-021-05349-3 Zobrazit plný text záznamu Full text from SpringerLink