Estrogen withdrawal Induces Macrophage Invasion in the Rabbit Corpus Luteum1
| Autor: | P L Keyes, David H. Townson, S E Bove, D M Naftalin |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty Lagomorpha urogenital system medicine.drug_class Ovary Cell Biology General Medicine Biology Luteal phase biology.organism_classification Endocrinology medicine.anatomical_structure Reproductive Medicine Estrogen Internal medicine Luteolysis medicine Macrophage Corpus luteum reproductive and urinary physiology hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Biology of Reproduction. 56:1175-1180 |
| ISSN: | 1529-7268 0006-3363 |
| Popis: | Macrophages within the corpus luteum are associated with spontaneous luteal regression in a number of species. However, an understanding of the consequences of macrophage recruitment on the functional capacity and responsiveness of the luteal tissue has remained elusive. Here we investigate the temporal appearance of macrophages and their potential impact in corpora lutea of rabbits, in which a rapid fall in progesterone synthesis and premature regression of the corpus luteum are initiated by withdrawal of the luteotropic hormone estradiol-17beta. Removal of estradiol implants, placed subcutaneously, induced a significant increase in the average number of macrophages per high-power field (hpf) in corpora lutea (p 0.05) between corpora lutea of estradiol-maintained rabbits and those of estradiol-replaced rabbits despite obvious differences in numbers of luteal macrophages (2 +/- 1 vs. 42 +/- 10 macrophages/hpf, respectively; p < 0.05). We conclude that the entry/recruitment of macrophages into the rabbit corpus luteum is sensitive to the luteotropic hormone estradiol-17beta and that the presence of macrophages does not preclude the continuation of progesterone production in surviving luteal tissue revitalized after estradiol removal/replacement. |
| Databáze: | OpenAIRE |
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