Indole: The After Next Scaffold of Antiplasmodial Agents?
| Autor: | Melese Legesse Mitku, Solomon Assefa Huluka, Kaleab Asres, Abdrrahman Shemsu Surur |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Indole test biology Hemozoin Pharmaceutical Science biology.organism_classification Cipargamin Plasmodium chemistry.chemical_compound chemistry Mechanism of action Biochemistry Cryptolepine Chloroquine parasitic diseases Drug Discovery medicine Antimalarial Agent medicine.symptom medicine.drug |
| Zdroj: | Drug Design, Development and Therapy. 14:4855-4867 |
| ISSN: | 1177-8881 |
| Popis: | Malaria remains a global public health problem due to the uphill fight against the causative Plasmodium parasites that are relentless in developing resistance. Indole-based antiplasmodial compounds are endowed with multiple modes of action, of which inhibition of hemozoin formation is the major mechanism of action reported for compounds such as cryptolepine, flinderoles, and isosungucine. Indole-based compounds exert their potent activity against chloroquine-resistant Plasmodium strains by inhibiting hemozoin formation in a mode of action different from that of chloroquine or through a novel mechanism of action. For example, dysregulating the sodium and osmotic homeostasis of Plasmodium through inhibition of PfATP4 is the novel mechanism of cipargamin. The potential of developing multi-targeted compounds through molecular hybridization ensures the existence of indole-based compounds in the antimalarial pipeline. |
| Databáze: | OpenAIRE |
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