Ameliorative Effect Of Trigonella Foenum Graecum L. On Lipid Profile, Liver Histology and Ldl-Receptor Gene Expression in High Cholesterol-Fed Hamsters
| Autor: | Kassaee Sn, Kassaee Sm, Goodarzi Mt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Trigonella Triglyceride medicine.diagnostic_test Normal diet biology Endocrine and Autonomic Systems business.industry Cholesterol Endocrinology Diabetes and Metabolism Blood lipids medicine.disease biology.organism_classification High cholesterol chemistry.chemical_compound Endocrinology chemistry Internal medicine LDL receptor medicine lipids (amino acids peptides and proteins) Lipid profile business |
| Zdroj: | Acta Endocrinologica (Bucharest). 17:7-13 |
| ISSN: | 1843-066X 1841-0987 |
| DOI: | 10.4183/aeb.2021.7 |
| Popis: | Background Trigonella foenum graecum L. (Fenugreek, FG) is used in many countries as a medicinal plant. Evidence has suggested the hypolipidemic effect of Fenugreek; however, its actual mechanism has not been determined yet. Objectives The purpose of our research was to investigate the effect of Fenugreek on lipid profile, liver histology and LDL receptor gene expression in male hamsters fed with high cholesterol diet. Methods These animals were given normal diet (ND), high cholesterol diet (HCD: 2% cholesterol and 0.5% cholic acid added to ND), HCD supplemented with 2g and 8g fenugreek per 100g ND (HCD+FG2 and HCD+FG8) respectively for four weeks. At the end of treatment, serum lipids, lipoproteins and liver enzymes were measured. Finally, LDL receptor (LDLR) gene expression was determined in the liver of the studied animals using Real Time-PCR method and liver histological changes were evaluated by H&E staining method. Results A significant reduction was observed in serum triglyceride (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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