New and Sensitive Method for the Spectrophotometric Determination of Certain Tricyclic Antidepressants

Autor: Akheel Ahmed Syed, Mohammed F Silwadi, Padmarajiah Nagaraja
Rok vydání: 2000
Předmět:
Zdroj: Microchimica Acta. 135:185-189
ISSN: 1436-5073
0026-3672
Popis: A new, simple, and sensitive spectrophotometric method for the determination of certain tricyclic antidepressants, belonging to the dibenzazepine class of drugs, has been developed. The proposed method is based on the reaction of imipramine hydrochloride (IPH), desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH), trimipramine maleate (TPM) or opipramol (OPP) with iron(III), and subsequent reaction with ferricyanide in an acetic acid medium, to yield a blue product, with maximum absorption at 720–730 nm.
Databáze: OpenAIRE