Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction

Autor:	Enxue Shi, Zhenhua Gao, Yongbiao Guo, Junchen Li, Chengxin Pei, Yuepeng Cao, Xiaojing Bi, Ling Yuan
Rok vydání:	2020
Předmět:	General method 010405 organic chemistry General Chemical Engineering Perkow reaction Regioselectivity General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Enol 0104 chemical sciences chemistry.chemical_compound chemistry Phosphorylation
Zdroj:	RSC Advances. 10:29493-29497
ISSN:	2046-2069
DOI:	10.1039/d0ra05140c
Popis:	A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cdb09631b31703da00e2d3ebcb080298 https://doi.org/10.1039/d0ra05140c Zobrazit plný text záznamu