Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

Autor:	Lena Huck, Mateo Berton, Jesús Alcázar, Angel Díaz-Ortiz, A. de la Hoz
Rok vydání:	2017
Předmět:	010405 organic chemistry Chemistry Drug discovery Environmental Chemistry Organic chemistry 010402 general chemistry 01 natural sciences Pollution Combinatorial chemistry 0104 chemical sciences
Zdroj:	Green Chemistry. 19:1420-1424
ISSN:	1463-9270 1463-9262
DOI:	10.1039/c6gc02619b
Popis:	The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::cdac7d2b160f35f48e6002ca32052a50 https://doi.org/10.1039/c6gc02619b Zobrazit plný text záznamu